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The many causes of regular ED can be both psychological or physiological. In lots of patients, it can be a combination of different factors, so we advise having a checkup by a doctor if you’re concerned. If you choose Tadalafil, you’ll be in good hands with us. At Manual, we only work with accredited trustworthy suppliers. You’ll receive your medication from the registered Manual Pharmacy, and you will be given a consultation beforehand to see if it is appropriate for you.
The vast majority of men get the results they want from Tadalafil – the ability to get a strong erection for up to 36 hours. As with all PDE5 inhibitors, you still need sexual stimulation for the drug to do its thing, so light some candles, put on some Barry White, and get your game face on. It’s go time!

Tadalafil is the name of the active ingredient in both generic Tadalafil and branded Cialis tablets, so they work in the same way. You can check out the differences in our blog article, Tadalafil vs. Cialis, but as they are essentially the same drug, you will need a prescription for both Cialis or Tadalafil in the UK.

The main difference between Tadalafil and Cialis is the price. In the UK, branded Cialis is priced around £38 for four 10mg tablets. That equates to about £9.50 per tablet. At Manual, Tadalafil is available from £3 per tablet for the same dosage.

The normal dose of Tadalafil is 10mg, which has the desired effect in the vast majority of men who are experiencing erectile dysfunction. There are also 2.5mg and 5mg variants, which are taken once daily. These are recommended for individuals with a more active sex life – perhaps 3 times per week or more. At Manual, we offer the 2.5mg once daily variant, as well as the 10mg standard dose.

As 10mg Tadalafil is designed to last 36 hours, you don’t need to take it daily. And we recommend that you only take it when you need it. As stated, the lower-dose versions of the drug (2.5mg and 5mg) can be taken daily, but this isn’t the most typical approach for those men who use Tadalafil.

Side effects are rare with Tadalafil, but when they do occur, the most common ones are headaches, flushing, dyspepsia (indigestion), nasal congestion, dizziness, nausea, muscle aches, hot flush, and vision changes (such as having a blue color tinge or blurred vision).

Very occasionally, more serious side effects such as sudden hearing loss or Priapism (unwanted prolonged erection for 4 hours or more) have been reported with Tadalafil usage. The likelihood of a serious side effect increases if the Tadalafil is mixed with drinking excessive alcohol, grapefruit juice, or also due to drug interactions with medications containing nitrates.

Nitrates are found in medications for high blood pressure and heart disease. They work by widening your blood vessels so that your blood pressure decreases. However, Tadalafil does the same thing – and their combination can result in serious – potentially fatal – drops in blood pressure.

Please read the patient information leaflet carefully for a full list of side effects and advice. Seek medical attention if you develop serious side effects after taking Tadalafil.

Women, men without erectile dysfunction, and anyone under the age of 18 should never take Tadalafil – or any other ED drug for that matter.

Men whose doctor has advised that they’re not fit enough for any physical or sexual activity, due to a recent heart attack, acute myocardial infarction (AMI), or stroke should also be cautious and avoid taking Tadalafil. Similarly, men who have low blood pressure or uncontrolled high blood pressure, pulmonary arterial hypertension, or who have had, or are under treatment for heart problems, angina (chest pain), or any blood flow issues shouldn’t use Tadalafil.

Seek guidance from your GP if you’re currently taking nitrates (nicorandil or other nitric oxide donors e.g. glyceryl trinitrate, isosorbide mononitrate or isosorbide dinitrate), or any of the following: recreational drugs such as ‘poppers’ (amyl nitrite); riociguat or other guanylate cyclase stimulators; ritonavir; CYP3A4 inhibitors, e.g. saquinavir; cimetidine; itraconazole or ketoconazole; erythromycin or rifampicin; diltiazem; alpha-blockers, such as alfuzosin; doxazosin or tamsulosin, which are medicines to treat urinary problems due to enlarged prostate (benign prostatic hyperplasia) or to treat high blood pressure

Men with hypersensitivity to the active substance or any of the excipients, anatomical deformation of the penis (such as angulation, cavernosal fibrosis, or Peyronie's disease), or any serious health condition should discuss their condition fully with their doctor before seeking Tadalafil treatment

Tadalafil is one of several PDE5 inhibitors that can be used to treat erectile dysfunction. Sildenafil, (Viagra), is a popular alternative to Tadalafil which isn’t as long-lasting. Vardenafil (Levitra) and Avanafil (Spedra) are also less widely-used PDE5 enzyme inhibitors that treat ED. If you're not sure, talk to one of the clinicians at Manual, who will provide expert advice and personalised treatment solutions.